OralScan is an optical imaging multimodal device for the early detection of (pre-) cancerous lesions of the oral cavity. The device operates on the principle of diffuse reflectance and tissue autofluorescence wherein light undergoes multiple absorption and scattering events before emerging from the tissue surface. Tumour tissues undergo biochemical and morphological changes during the process of carcinogenesis, which is reflected in the optical signals emanating from the tissue. The device uses an optical system with custom-built software and algorithms for tissue analysis. OralScan enables the physician to visualize and discriminate between healthy and potentially malignant sites of the oral cavity before they perform a biopsy. The diagnostic advantages of OralScan include non-invasive in vivo procedures and services, wide-field imaging of the oral cavity, utilization of a cloud-based machine learning algorithm for real-time feedback on tissue status, and application of oxygenated haemoglobin (HbO2) absorption maps for biopsy guidance.